mir-BHRF1-2 microRNA precursor family
The mir-BHRF1-2 microRNA precursor found in human herpesvirus 4 (Epstein-Barr virus), cercopithicine herpesvirus 15 and herpesvirus papio. In Epstein-Barr virus, mir-BHRF1-2 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 3' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-3.[1]
BHRF-1-2 miRNA is though to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.[2] BHRF-1-2 has been shown to be expressed in latency-III infected lymphoblasts.[3]
References
- ^ a b Pfeffer, S; Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T (2004). "Identification of Virus-Encoded MicroRNAs". Science 304 (5671): 734–736. doi:10.1126/science.1096781. PMID 15118162.
- ^ Feederle, R; Haar, J, Bernhardt, K, Linnstaedt, SD, Bannert, H, Lips, H, Cullen, BR, Delecluse, HJ (2011 Jul 13). "The members of a viral miRNA cluster co-operate to transform B lymphocytes.". Journal of virology. PMID 21752900.
- ^ Xing, L; Kieff, E (2007 Sep). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication.". Journal of virology 81 (18): 9967–75. doi:10.1128/JVI.02244-06. PMC 2045418. PMID 17626073. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2045418.
External links